FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES
نویسندگان
چکیده
منابع مشابه
Development and Characterization of Paracetamol Complexes with Hydroxypropyl-?-Cyclodextrin
Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (?, ? and HP-?-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of Paracetamol w...
متن کاملDevelopment and Characterization of Paracetamol Complexes with Hydroxypropyl-?-Cyclodextrin
Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (?, ? and HP-?-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of Paracetamol w...
متن کاملInclusion Complexes of Hesperidin with Hydroxypropyl-β - Cyclodextrin. Physico-chemical Characterization and Biological Assessment
The aim of this research was to prepare the inclusion complexes formed by hesperidin and (2-hydroxypropyl)-β-cyclodextrin by different techniques (kneading, co-evaporation and lyophilization methods), to carry out phase solubility studies, in vitro dissolution, antioxidant and antimicrobial tests. To confirm the inclusion compounds formation, spectroscopic (UV-Vis, FTIR, 1 H-NMR) and thermal (D...
متن کاملSolid State Characterization of Domperidone: Hydroxypropyl-β-Cyclodextrin Inclusion Complex
The purpose of the present study was to prepare inclusion complex of domperidone with hydroxylpropyl-β-cyclodextrin in order improved the solubility and hence to increase dissolution of domperidone. An effect of concentration of hydroxylpropyl-β-cyclodextrin on the aqueous solubility of domperidone was determined by phase-solubility method. The aqueous solubility of domperidone increased as a f...
متن کاملThermodynamic, spectral and antimicrobial activity of inclusion complexes of acridone and its oxime with β-cyclodextrin
One of the methods to enhance bio-accessibility of drugs like Acridone and its oxime is toform inclusion complexes with β-cyclodextrin. The formation of such complexes has beenconfirmed by changes in spectral characteristics and melting point data. The aqueous phasesolubility studies reveal 1:1 stoichiometry between the compound and, β-cyclodextrin. The studyof thermodynamic parameters like ΔG,...
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ژورنال
عنوان ژورنال: Journal of the Chilean Chemical Society
سال: 2011
ISSN: 0717-9707
DOI: 10.4067/s0717-97072011000100011